Jim, we used what Bert suggested above, creating extra "users" with various permissions. Works out well for us - our "insurance card/demographics" employee has "High: mid level provider" status so whatever she scans in does not generate a message to me. We made a user named "Lab" for scanning in labs, test results, stuff docs need to sign off on and set the level of access to low so everything they scan generates a message. We have a user named "Records" for scanning in old records from other docs I want to review. Plus we still have all the MA's with their own sign in names for all the medical issues, refills, etc. I know it kinda sounds like a pain having the extra user names, but the main reason we did that was b/c of the issue you were having - I hated seeing an inbox with 250 items in it all from one user...where do you even start! By having the different users, when I click on the "From" tab, it organizes the messages by user name alphabetically. That way I can ignore the stuff from "Records" until I have some free time and focus on the stuff from my MA like refills etc. or work on my labs from the "Lab" user.
Since we started running version 4, it has gotten easier. You can color code messages now (like red for asap, blue for refills, or whatever), and the sign off process has been streamlined. I still have 200 items in my inbox but thats just b/c I'm wasting time on the web while all those scans from "Records" sit there for a month ;-)