I agree internal is rather safe. I have two backups internally myself, but only because Backup Assist puts them there and then moves them externally. I just hope you have at least two external drives. But, I guess you are alright.
Sage has been bought by Vitera. I know quite a bit about Medware, then Sage, etc. Just two weeks ago, I copied the whole folder and put it on a flash drive and ran it. Don't see why you can't put it on any other computer, but (I am stubborn) I don't see why it won't run on 2011. Makes no sense. I am sure you mapped it as you have used it before. Don't know why you have to be an admin, but why not run as an admin. Easier anyway. I have run local machines as admins for 15 years. I really don't want to run around to everyone's computer clicking on Run As, etc.
You don't have to back up your II with AC. Why not back them up with your server backup. The reason I would just put storage on the other drive is I would want the Server Backup to be a full bare metal backup. But, I suppose you could do that with the SSDs and backup AC to the HDD. But, you could still back up II to your external or internal drive and not include in your AC.enc backup. They will only get bigger.
There are tons of 3rd party programs that will delete your AC backups from your AC folder. You can leave one, two, ten whatever. Some are free, some are around $25.00. Then you never have to check.
I suppose you don't need an E drive. What would it be for. You could simply have C: for system drive and D: for data. I put all my programs on C:. I have never seen an advantage for putting programs on a different partition. I like to let my programs install to the default folders especially with 64-bit programs. Plus, no matter how hard I try, I always forget and then I have two programs on C and some on D. But, then you have the size factor. I suppose I won't say anything about SSDs.