I have V6.09 installed on 2 dell computers runing vista business, intel duo 1.8 Ghz, 4GB RAM (one of them is "server")and 5 fujitsu laptops, intel duo 1.8 Ghz and 2GB RAM runing windows 7 ultimate. No problems with upgrade and didn't notice speed issue even with using eprescribing. All computers will be 4 years old in november. Laptops were just recently upgraded to windows 7 ultimate.