I have two employees. Started using Quicken perhaps more than 15 years ago. Greatest thing since sliced bread. Instead of manually creating a ledger from your practice check book, just hit a button on January 1st and all prints out for the year. Easy to set up expense categories and payments become routine. I don't use Quicken bank or on line payment features just the check writing. For simple check writing, creating and tracking expense (or income) categories etc then the cheapest and simplest edition will do. At the office I'm still using Quicken 2002! The fancier versions let you do more on line banking, estate planning, investment management, etc.
As to Quick Books, I'm not sure. My ortho son uses QB and thinks it's great. Long ago I created an Excel spreadsheetwith formulas for employee Fed, State, City, FICA etc withholding. Being cheap there, I file Fed on line but let accountant calculate Work Comp, Unemploy etc for me. Got fed up when years ago the state unemployment demanded an audit since the figures I submitted to them didn't jive with the federal ones. There was a $1.18 discrepancy for a whole quarter. Cost me $300 for accountant to point out to state that I actually overpaid them the $1.18 and the Fed amount was right. That's when I let the accountant do the unemployment.