I agree that estrogens should be avoided in a patient with h/o thrombosis. Even low dose estrogens have been shown to significantly increase the risk of thrombosis. Anyhow, you have several relatively safe alternatives:
-- The newly released Mirena IUD releases progestins, but only low levels of progestins get into the blood stream. It may, therefore, be a particularly suitable for use in individuals with thrombosis or thrombophilia. Even though I am not aware of any systematic investigation regarding its risk of causing thrombosis, I would not expect Mirena to increase that risk. It can also be used for contraception.
-- Depo-Provera has been noted to have "No increased risk of deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, or myocardial infarction." (see
http://www.quickoverview.com/reproductive/depo-provera.html) In their product circular, though, they will state that it be "Used with Caution in... patients with a history of blood clots in the blood vessels (thromboembolism)." (see
http://www.netdoctor.co.uk/medicines/100000717.html) Approximately, 80% to 90% of patients completing 12 months of Depo-Provera therapy will be amenorrheic.
-- Cyclical progesterone therapy stabilizes the proliferative endometrium and induces regular sloughing. Cyclical progesterone therapy is useful in women with contraindications to estrogen therapy (ie, women older than 35 years of age who smoke, history of deep venous vein thrombosis, or high risk factors for cardiovascular disease). Generally, medroxyprogesterone acetate 10 mg for 10 to 14 days each month will induce a regular withdrawal bleed. This dosage will not provide contraception.
I agree wholeheartedly in getting a GYN involved to rule out gynecological causes of heavy uterine bleeding. I would also get a hematologist (like myself) to share the risk of recurrent DVT. He can in the meantime do a full coagulopathy workup (see
http://www.emedicine.com/med/TOPIC2785.HTM for an excellent review). All 3 of you need to determine what is this woman's worse risk- having complications from her heavy bleeding or from her h/o DVT.
Good luck!
Al