You could copy the databases onto the flash drive, but as to a standalone Amazing Charts portable application, I don't think that will work. Even if it did, I would be reluctant to use it given the speed of a standard USB flash drive. Perhaps if you provided us some more information regarding your situation, we could recommend other alternatives. If I had to run it off a flash drive, I would use a USB 3.0 SuperTalent ST3U32EDK at minimum.