Ron,
We actually ran into a issue with Trend Micro too in that last few weeks a month. There is a thread on this where lots on people chimmed in and I detailed the issues we experienced. We are now using Kaspersky which has the best anti-virus search engine, program going. It is so good that you get the Kaspersky anti-virus when you buy the Zone Alarm products. ZA just lets Kaspersky do the work. After our trend issues, we very briefly tried AVG as I bought a cheap boxed set 0f 7.5 locally on the advice of AC tech support.
Although I hated the interface and the terminology, it did seem to work alright (24 hours after I bought it there was a review in computer shopper that said all the things I hated about it, live and learn, right?) So one night while updating it offered me to "Upgrade" for "Free" to 8.0, which was supposed to attend to some of the issue I and CS hated so much. Well, this update froze Nancy's Gateway laptop up solid with one of those, the CPU is overloaded at 100% steady full time kind of things, screw that!
So I did a system restore to return to the 7.5 and seeing that we had two new clean machines just sitting there waiting to be used, I tried Kaspersky and except for this one really weird issue, we are extremely happy with it. This thing finds things that most of the others miss. It is really great at finding all sorts of things your old program missed. Unless something really bad happens that would force us to switch, this is where I am staying. And Hey when you call tech support, there are nice American young folks at the phone center in eastern MA, to answer your call. Although they like to bury the phone number, I guess to keep support to more email and less live calls, but I found it and will gladly share....
Good luck,