The short answer is that there is no longer ONE answer for folks looking (or having) upgraded.
There are all of the subjects that those of us who have been around are well aware of - processors, RAM, network, DNS, configuration.
Add to that the increased impact of MU2(the MU Tax) on later versions, certain interfaces (that can consume over a GIG of RAM and significant CPU at every run), and we are trying to diagnose a multi-variable problem.
We have practices with 6-8 computers that notice slowness after upgrading and we have practices with 10-12 computers that have a work stoppage and need immediate help.
There are some cases where 64bit Express makes a difference, and others where it has no effect.
Full SQL has the most marked improvement, but that alone does not deal with the MU2 tax.
For some practices, we are evaluating the option of staying on 6.3.3 from a cost-benefit perspective, and coding encounters completely outside of AC. I'll be doing a more detailed session on it next month, but some practices will be better off having someone other than the Physician/Provider doing the coding, especially with the advent of ICD10.