I hit 'reset paths', as it was looking for the database on the c drive instead of our server.
Now when AC loads, it doesn't ask to navigate to the 'main computer'.
I uninstalled and reinstalled AC more of the same.
The reset should provide you with the prompts to connect to the database.
One of the things about re-installing AC is it often works better to completely delete the directory after the un-install, then restart.
You can also use Revo or similar to clear out the registry.