Nate,
I appreciate you bringing up this topic for discussion, and respect your perspective.
One additional thought that keeps rattling around in my brain, and is a bit random and quite unrelated but has merit, I think.
I am not a hunter, but when my son showed interest, I took the 2 week hunter education course with him. One of the rules taught in the course is always be sure of your target and beyond.
If you apply this particular rule to the treatment of pain, hopefully, will reduce unintended consequences with the treatment plan.