Well, I don't have a simple answer.
However, the plant world is just full of poisons, and seems like mostly human beings are getting poisoned -- you don't see bears getting off on opium and marijuana -- but even people didn't used to have such a drug problem.
Something about human culture is seriously haywire.
All I am saying is that treating drug use as a criminal offense hasn't helped a whole lot, and has contributed to other social problems.
Time for a new paradigm.