The two I have used are Medisoft and eMedware. When I set up practice, my practice manager had certain things she uses/used in other offices such as Muratec for copier and eMedware of billing. It is nice, because it is relatively inexpensive and easy to use. The biggest benefit was that we had a lot of help from the other offices who used it.
So, maybe one thing you can think of is not only ask other offices in your area for advice, but if you have other offices you are close to (not proximity) that you can ask questions while you are using it, it can be helpful.