Damn I'm still running some programs in an XP VM on a Win 7 Pro Host, still planning to move it(XP VM and said other programs) to a Win 10 machine with Hyper V however getting grief my office manager about having to do the 3 key press to release the mouse from within the XP VM to return to the Win 10 host.
If the XP VM doesn't have 'permission' to use the network adapter do I have to worry about..."running non-supported software may invalidate your HIPAA/HiTrust/Other assessments and credentials"?
You'll have to read the pertinent documentation, but a more stringent standard is actually PCI-DSS (credit-card), which requires at-rest encryption, "air-gap" system components other than the encrypted payment channel.
Isolating the system is easily the best way to minimize risk.