In the long run for quite a bit of data from a server or otherwise, I have found most of these online backup services to be insufficient. No matter what they say on their website, they don't seem to work well with commercial uses.
I think that Rsync and sending the data to your house would be a better way to go. Backup Assist is a third party app that would help with the whole process. You can also use Amazon3 and other cloud storage sites.
I think an online service which catered to businesses only and provided a customer service rep that was extremely knowledgeable on these matters who would be assigned to your company and provide support would flourish. He or she would ensure that your setup was correct and that your data could be retrieved quickly either via the net or via courier service. The files would be encrypted, but your concierge employee would still monitor for things like skipped days, etc.
This would be the way to go. One shouldn't have to worry about VSS, databases, Sharepoint, SQL, Exchange, Open Files, De-duplication, incremental backups, differential backups, full backups, image backups, block file backups, system files, continuous vs. scheduled backups, etc. Just call it Critical Files Backup Online.
