No it cannot. None of the Server 2008R2 series can use a 3TB drive for backup. It has to do with the way it makes backups using vmdk files. The VMDK (virtual disk) files are limited at 2TB. This limit has been removed in Server 2013.
Some Western Digital Drives have a had a custom firmware to get around this issue. Seagate does not have one.
.png "ACUF Donor I")
