My current backup plan can be described like this:
I have two servers, running Win server 2008; primary server and backup server.
My IT guys came up with the following backup plan:
The Amazing Charts backup program runs nightly, absent the Imported Items. It backs up to the primary server and the AC remote site. Jungle disk then backs up the AC backup folder on the server and the imported items folder to the Jungle Disk server nightly. This serves as the offsite backup in case of fire or natural disaster.
For the more timely local backups, Windows Server 2008 comes with its own backup utility that allows the entire primary drive to be incrementally backed up to the second server without shutting down the program on the primary server. This runs every 30 minutes.
Since my IT guys dreamed this up (and tested it) I can't offer any gory details, beyond the observation that it seems to fulfill my most paranoid desires.
And here is a link to a thread that brought me to my current backup system:
http://www.amazingcharts.com/ub/ubbthreads.php/topics/22431/Re_Multiple_backups_multiple_p#Post22431
