You can setup the Scan/Save to Folder with the ScanSnap software rather than using a TWAIN driver. Basically you push the button and it pops up into the folder where you can drag and drop into the patients Imported Items.
My personal preference is for the Brother ADS network series. Can be programmed to scan directly to a network share or over SFTP for remote offices. Great for security in an RDS applications since the computer itself doesn't need access to a shared folder. No computer required.